產品詳情
簡單介紹：
Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體產品質量穩定，實驗效果明顯，貨期快，價格優惠，歡迎垂詢訂購！我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹：
Rabbit Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)
Cat. Number:
Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體KL-3314R
Quantity size:
0.1ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.
Also known as:
PAK4 (phospho S474); p-PAK4 Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體(phospho S474); Phospho-PAK4(Ser474); Phospho-PAK5(Ser602); Phospho-PAK6(Ser560); PAK4 + PAK5 + PAK6 (phospho S474 + S602 + S560); p21 activated kinase 4 ; p21(CDKN1A) activated kinase 4; PAK 4; Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs; Serine threonine kinase PAK 4; Serine/threonine protein kinase PAK 4; Serine/threonine protein kinase PAK4; KIAA1142; PAK4_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, .
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Immunogen: KLH conjugated Synthesised Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體phosphopeptide derived from human PAK4 around the phosphorylation site of PAK4 Ser474 [RK(p-S)LV].
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Predicted Molecular Weight: 64kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications. Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)抗體
Optimal working dilutions must be determined by the end user.
