產品詳情
簡單介紹：
Anti-KRIT1抗體產品質量穩定，實驗效果明顯，貨期快，價格優惠，歡迎垂詢訂購！我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-KRIT1抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹：
Rabbit Anti-KRIT1
Cat. Number:
Anti-KRIT1抗體KL-8546R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and Anti-KRIT1抗體independent manner, and inhibits EKR1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin D1 levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
Also known as:
Ankyrin repeat containing protein Krit1; Anti-KRIT1抗體CAM; CCM 1; CCM1; Cerebral cavernous malformations 1; Cerebral cavernous malformations 1 protein; Krev interaction trapped 1; Krev interaction trapped protein 1; KRIT 1; KRIT1 ankyrin repeat containing; KRIT1; KRIT1_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human KRIT1.
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Predicted Molecular Weight: 84kDa.Anti-KRIT1抗體
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
Not yet tested in other applications. Anti-KRIT1抗體
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications. Anti-KRIT1抗體
Optimal working dilutions must be determined by the end user.
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kl150Hu01 Ⅵ型膠原α1(COL6α1)多克隆抗體 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1)
kl150Mu01 Ⅵ型膠原α1(COL6α1)多克隆抗體 Polyclonal Antibody to Collagen Type VI Alpha 1 (COL6a1)
kl152Hu01 Ⅴ型膠原α2(COL5α2)多克隆抗體 Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2)
kl152Mu01 Ⅴ型膠原α2(COL5α2)多克隆抗體 Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2)
kl155Hu01 Ⅸ型膠原α3(COL9α3)多克隆抗體 Polyclonal Antibody to Collagen Type IX Alpha 3 (COL9a3)
kl156Hu01 Ⅹ型膠原(COL10)多克隆抗體 Polyclonal Antibody to Collagen Type X (COL10)
kl156Mu01 Ⅹ型膠原(COL10)多克隆抗體 Polyclonal Antibody to Collagen Type X (COL10)
kl156Ra01 Ⅹ型膠原(COL10)多克隆抗體 Polyclonal Antibody to Collagen Type X (COL10)
kl157Hu01 Ⅺ型膠原α1(COL11α1)多克隆抗體 Polyclonal Antibody to Collagen Type XI Alpha 1 (COL11a1)
kl158Hu01 Ⅻ型膠原(COL12)多克隆抗體 Polyclonal Antibody to Collagen Type XII (COL12)
kl158Mu01 Ⅻ型膠原(COL12)多克隆抗體 Polyclonal Antibody to Collagen Type XII (COL12)
kl169Hu01 神經秩蛋白(NRTN)多克隆抗體 Polyclonal Antibody to Neurturin (NRTN)
kl170Hu01 Persephin蛋白(PSPN)多克隆抗體 Polyclonal Antibody to Persephin (PSPN)
kl170Mu01 Persephin蛋白(PSPN)多克隆抗體 Polyclonal Antibody to Persephin (PSPN)
kl172Hu01 神經調節素2(NRG2)多克隆抗體 Polyclonal Antibody to Neuregulin 2 (NRG2)
kl173Hu01 神經調節素3(NRG3)多克隆抗體 Polyclonal Antibody to Neuregulin 3 (NRG3)
kl174Hu01 神經調節素4(NRG4)多克隆抗體 Polyclonal Antibody to Neuregulin 4 (NRG4)
kl175Hu01 左右決定因子1(LEFTY1)多克隆抗體 Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1)
