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產品詳情
  • 產品名稱:Anti-ACVR1B抗體

  • 產品型號:Anti-ACVR1B
  • 產品廠商:KALANG
  • 產品文檔:
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簡單介紹:
Anti-ACVR1B抗體產品質量穩定,實驗效果明顯,貨期快,價格優惠,歡迎垂詢訂購!我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-ACVR1B抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹:
Rabbit  Anti-ACVR1B
Cat. Number:
Anti-ACVR1B抗體KL-6018R
Quantity size:
0.2ml
Concentration:
1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
[FUNCTION]Transmembrane Anti-ACVR1B抗體serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Also known as:
Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR IB; ACTR-IB; ACTRIB; ACV1B_HUMAN; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK-4; ALK4; Serine(threonine) protein Anti-ACVR1B抗體kinase receptor R2; Serine/threonine-protein kinase receptor R2; SKR 2; SKR2.
Specificity:
Rabbit Polyclonal IgG, Anti-ACVR1B抗體affinity purified by Protein A.
Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, .
Immunogen: KLH conjugated synthetic peptide derived from human ACVR1B.
Predicted Molecular Weight: 55kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be Anti-ACVR1B抗體determined by the end user.
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kl010Ga01 結締組織生長因子(CTGF)多克隆抗體 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF)
kl010Hu01 結締組織生長因子(CTGF)多克隆抗體 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF)
kl010Mu01 結締組織生長因子(CTGF)多克隆抗體 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF)
kl010Po01 結締組織生長因子(CTGF)多克隆抗體 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF)
kl010Ra01 結締組織生長因子(CTGF)多克隆抗體 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF)
kl010Rb51 結締組織生長因子(CTGF)多克隆抗體 Polyclonal Antibody to Connective Tissue Growth Factor (CTGF)
kl011Bo01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Ca01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Eq01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Ga01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Gu01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Hu01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Mu01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Po01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
kl011Ra01 腦源性神經營養因子(BDNF)多克隆抗體 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF)
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kl012Hu01 S100鈣結合蛋白(S100)多克隆抗體 Polyclonal Antibody to S100 Calcium Binding Protein (S100)
kl012Mu01 S100鈣結合蛋白(S100)多克隆抗體 Polyclonal Antibody to S100 Calcium Binding Protein (S100)

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