產品詳情
簡單介紹：
Anti-CHK2抗體產品質量穩定，實驗效果明顯，貨期快，價格優惠，歡迎垂詢訂購！我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-CHK2抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹：
Rabbit Anti-CHK2
Cat. Number:
Anti-CHK2抗體KL-1391R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative Anti-CHK2抗體tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of Anti-CHK2抗體serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Also known as:
bA444G7; CHK2 checkpoint homolog; CHK2_HUMAN; Serine/threonine-protein kinase Chk2; CDS 1; CDS1; Checkpoint kinase Anti-CHK2抗體2; Checkpoint like protein CHK2; Chek 2; Chek2; Chk 2; CHK2 checkpoint homolog (S. pombe); CHK2 checkpoint homolog; HuCds 1; HuCds1; LFS 2; LFS2; PP1425; RAD 53; RAD53; Rad53 homolog; Serine/threonine protein kinase Chk2.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, .
●
Immunogen: KLH conjugated synthetic peptide derived from human CHK2.
●
Predicted Molecular Weight: 65kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500Anti-CHK2抗體 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl801Hu01 激肽釋放酶原(PK)多克隆抗體 Polyclonal Antibody to Prekallikrein (PK)
kl802Hu01 白介素32(IL32)多克隆抗體 Polyclonal Antibody to Interleukin 32 (IL32)
kl807Hu01 Jagged 1蛋白(JAG1)多克隆抗體 Polyclonal Antibody to Jagged 1 Protein (JAG1)
kl807Mu01 Jagged 1蛋白(JAG1)多克隆抗體 Polyclonal Antibody to Jagged 1 Protein (JAG1)
kl812Hu01 β-位淀粉樣前體蛋白裂解酶2(βACE2)多克隆抗體 Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 2 (bACE2)
kl815Hu01 白介素6受體(IL6R)多克隆抗體 Polyclonal Antibody to Interleukin 6 Receptor (IL6R)
kl815Mu01 白介素6受體(IL6R)多克隆抗體 Polyclonal Antibody to Interleukin 6 Receptor (IL6R)
kl815Ra01 白介素6受體(IL6R)多克隆抗體 Polyclonal Antibody to Interleukin 6 Receptor (IL6R)
kl817Hu01 多功能蛋白聚糖(VS)多克隆抗體 Polyclonal Antibody to Versican (VS)
kl817Mu01 多功能蛋白聚糖(VS)多克隆抗體 Polyclonal Antibody to Versican (VS)
kl818Mu01 血管內皮生長因子受體1(VEGFR1)多克隆抗體 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)
kl818Ra01 血管內皮生長因子受體1(VEGFR1)多克隆抗體 Polyclonal Antibody to Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)
kl819Mu01 再生胰島衍生蛋白4(REG4)多克隆抗體 Polyclonal Antibody to Regenerating Islet Derived Protein 4 (REG4)
kl822Hu01 角蛋白17(KRT17)多克隆抗體 Polyclonal Antibody to Keratin 17 (KRT17)
kl823Hu01 補體成分9(C9)多克隆抗體 Polyclonal Antibody to Complement Component 9 (C9)
